Medical College of Wisconsin
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Effects of hydrocortisone and cholecystokinin-octapeptide on neonatal rat pancreas. J Pediatr Gastroenterol Nutr 1982;1(4):591-5

Date

01/01/1982

Pubmed ID

6193263

DOI

10.1097/00005176-198212000-00025

Scopus ID

2-s2.0-0020261885 (requires institutional sign-in at Scopus site)   25 Citations

Abstract

Hydrocortisone and cholecystokinin-octapeptide (CCK-8) were injected into newborn rats on days 1-5 of life. Both agents induced significant increases in pancreatic weight, protein, DNA, and specific activities of amylase, chymotrypsinogen, and lipase. The ability of the pancreas to secrete amylase in response to carbachol was decreased by the administration of hydrocorticosterone at age 7 days. CCK-8 increased basal secretion at 7 days. We conclude that growth and secretory capacity of the newborn rat pancreas are under the control of both glucocorticoids and cholecystokinin.

Author List

Werlin SL, Stefaniak J

Author

Steven L. Werlin MD Emeritus Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Amylases
Animals
Animals, Newborn
Carbachol
Cholecystokinin
Chymotrypsinogen
Hydrocortisone
Lipase
Organ Size
Pancreas
Peptide Fragments
Proteins
Rats
Rats, Inbred Strains
Sincalide
Time Factors