4-Locus high-resolution HLA allele and haplotype frequencies in Costa Ricans from Guanacaste. Hum Immunol 2019 Jul;80(7):415-416
Date
05/28/2019Pubmed ID
31126638DOI
10.1016/j.humimm.2019.05.005Scopus ID
2-s2.0-85065836348 (requires institutional sign-in at Scopus site)Abstract
A total of 110 Costa Rican Mestizos from the province of Guanacaste were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, and -DRB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequent extended haplotype identified was A*24:02:01-B*35:12:01-C*04:01:01-DRB1*04:07:01G, with an estimated frequency of 2.73%. No deviation from Hardy-Weinberg Equilibrium was detected at any of the loci studied. The HLA genotypic data of the population sample reported here are available publicly in the Allele Frequencies Net Database under the population name "Costa Rica Guanacaste Mestizo" and the identifier AFN3609.