Ion channels and transporters in diabetic kidney disease. Curr Top Membr 2019;83:353-396
Date
06/15/2019Pubmed ID
31196609Pubmed Central ID
PMC6815098DOI
10.1016/bs.ctm.2019.01.001Scopus ID
2-s2.0-85061645281 (requires institutional sign-in at Scopus site) 20 CitationsAbstract
Type 1 and 2 diabetes mellitus are major medical epidemics affecting millions of patients worldwide. Diabetes mellitus is the leading cause of diabetic kidney disease (DKD), which is the most common cause of end-stage renal disease (ESRD). DKD is associated with significant changes in renal hemodynamics and electrolyte transport. Alterations in renal ion transport triggered by pathophysiological conditions in diabetes can exacerbate hypertension, accelerate renal injury, and are integral to the development of DKD. Renal ion transporters and electrolyte homeostasis play a fundamental role in functional changes and injury to the kidney during DKD. With the large number of ion transporters involved in DKD, understanding the roles of individual transporters as well as the complex cascades through which they interact is essential in the development of effective treatments for patients suffering from this disease. This chapter aims to gather current knowledge of the major renal ion transporters with altered expression and activity under diabetic conditions, and provide a comprehensive overview of their interactions and collective functions in DKD.
Author List
Spires D, Manis AD, Staruschenko AMESH terms used to index this publication - Major topics in bold
AnimalsDiabetic Nephropathies
Humans
Ion Channels
