Mapping Mammary Tumor Traits in the Rat. Methods Mol Biol 2019;2018:249-267
Date
06/23/2019Pubmed ID
31228161Pubmed Central ID
PMC9272588DOI
10.1007/978-1-4939-9581-3_12Scopus ID
2-s2.0-85068143262 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
For nearly a century, the rat has served as a key model for studying the pathophysiology and genetic risk modifiers of breast cancer. Rat mammary tumors that initiate after exposure to carcinogens or estrogens closely resemble the etiological, histopathological, and genomic features of human breast cancer. Recent developments in genome-editing techniques in the rat have also enabled the development of sophisticated models for identifying the genetic modifiers of the nonmalignant tumor microenvironment that contribute to the formation, progression, and outcome of breast cancer. In this protocol review, we discuss the current methodologies for the three genetic mapping techniques in the rat that are widely used for identifying and testing the heritable genetic modifiers of breast cancer.
Author List
Flister MJ, Joshi A, Bergom C, Rui HAuthor
Amit Joshi PhD Professor in the Biomedical Engineering department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsChromosome Mapping
Female
Gene Editing
Genetic Predisposition to Disease
Humans
Mammary Neoplasms, Experimental
Quantitative Trait, Heritable
Rats
Tumor Microenvironment