Anesthetic neurotoxicity. Anesthesiol Clin 2012 Jun;30(2):207-28
Date
08/21/2012Pubmed ID
22901607DOI
10.1016/j.anclin.2012.06.002Scopus ID
2-s2.0-84865288669 (requires institutional sign-in at Scopus site) 42 CitationsAbstract
Concerns for toxic effects of anesthesia to the brains of the young and the elderly are mounting. While experimental evidence for such effects in the developing brain is strong, the underlying mechanisms are less well understood and debate continues as to whether young humans are at risk for anesthetic neurotoxicity. The phenomenon of postoperative cognitive deterioration in the elderly remains controversial. Time course, severity, and whether or not it persists long term are under debate. For both patient groups, today's evidence is not sufficient to guide change in clinical practice. Well-designed research is therefore imperative to tackle this critical issue.
Author List
Brambrink AM, Orfanakis A, Kirsch JRMESH terms used to index this publication - Major topics in bold
AgedAging
Anesthesia
Anesthetics
Animals
Brain
Child
Child, Preschool
Cognition Disorders
Humans
Infant
Nervous System Diseases
Neurotoxicity Syndromes
Perioperative Care
Postoperative Complications