Faculty Collaboration Database

Intra-arterial urokinase for treatment of retrograde thrombosis following resection of an arteriovenous malformation. Case report. J Neurosurg 1992 Jun;76(6):1004-7

Date

06/01/1992

Pubmed ID

1588404

DOI

10.3171/jns.1992.76.6.1004

Scopus ID

2-s2.0-0026689015 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

Retrograde thrombosis of feeding arteries is a potentially catastrophic complication occasionally reported following resection of arteriovenous malformations (AVM's). No successful therapy for this condition, which causes postoperative stroke, has previously been reported. A case of retrograde thrombosis of the left middle cerebral artery immediately following resection of a parietal AVM is reported in a patient with a retained intra-arterial catheter from preoperative embolization. The administration of urokinase within 4 hours of surgery resulted in dramatic clinical and angiographic improvement without hemorrhagic complications. While urokinase is considered highly experimental in this setting, this case demonstrates that thrombolytic agents should be viewed as therapeutic options worthy of further investigation.

Author List

Sipos EP, Kirsch JR, Nauta HJ, Debrun G, Ulatowski JA, Bell WR

MESH terms used to index this publication - Major topics in bold

Adult
Embolization, Therapeutic
Female
Humans
Infusions, Intra-Arterial
Intracranial Arteriovenous Malformations
Intracranial Embolism and Thrombosis
Postoperative Complications
Radiography
Urokinase-Type Plasminogen Activator