Faculty Collaboration Database

Age-related cerebrovascular reactivity to CO2 after cerebral ischemia in swine. Am J Physiol 1991 May;260(5 Pt 2):H1482-8

Date

05/01/1991

Pubmed ID

1903601

DOI

10.1152/ajpheart.1991.260.5.H1482

Scopus ID

2-s2.0-0025806654 (requires institutional sign-in at Scopus site)   23 Citations

Abstract

We tested the hypothesis that cerebral blood flow (CBF) reactivity to CO2 after global ischemia takes longer to recover in 1- to 2-wk-old piglets than in 6- to 10-mo-old pigs. All animals were sedated with ketamine and anesthetized with pentobarbital sodium. Cerebral ischemia was produced by sequentially tightening ligatures around the inferior vena cava and ascending aorta for 10 min. The microsphere-determined CBF response to hypercapnia (arterial PCO2 approximately 65 mmHg) was depressed at 60 min of reperfusion (9 +/- 6% of preischemia; means +/- SE) and remained depressed at 120 min (33 +/- 23% of preischemia, means +/- SE) in young pigs. In older pigs, the response was also depressed at 60 min of reperfusion (21 +/- 9% of preischemia) but was not depressed at 120 min. The pattern for recovery of hypercapnic reactivity was present in most brain regions except cerebellum, where CO2 reactivity returned to control in young animals by 120 min of reperfusion. The response to hypocapnia (arterial PCO2 approximately 25 mmHg) was also better preserved in older pigs. In older pigs recovery of CO2 reactivity during reperfusion paralleled recovery of cerebral O2 consumption over time. We conclude that older pigs have quicker return of CBF CO2 reactivity following transient global ischemia, which may be due to age-related differences in mechanisms of vascular reactivity.

Author List

Helfaer MA, Kirsch JR, Haun SE, Koehler RC, Traystman RJ

MESH terms used to index this publication - Major topics in bold

Aging
Animals
Animals, Newborn
Brain
Brain Ischemia
Carbon Dioxide
Cerebrovascular Circulation
Female
Male
Oxygen Consumption
Swine