Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Tumefactive demyelination: Clinical outcomes, lesion evolution and treatments. Mult Scler J Exp Transl Clin 2019;5(2):2055217319855755

Date

06/28/2019

Pubmed ID

31245023

Pubmed Central ID

PMC6582300

DOI

10.1177/2055217319855755

Scopus ID

2-s2.0-85083434401   11 Citations

Abstract

OBJECTIVE: Large demyelinating lesions with possible mass effect (tumefactive multiple sclerosis or tumefactive demyelination) can be mistaken for tumour-like space-occupying lesions suggesting a malignant outcome.

METHODS: We reviewed our own experience of multiple sclerosis subjects (n = 28) with tumefactive demyelination to determine the relationship between clinical outcomes and lesion evolution, clinical outcomes and their relationship to different therapies. Patients with central nervous system demyelinating disease were identified from our database over the last 10 years.

RESULTS: No patient increased in extended disability status scale (EDSS). Overall, lesion regression was associated with improved EDSS. Lesion regression was also associated with therapy versus no therapy. No specific therapy or corticosteroid infusions improved EDSS over the long term. The absence of enhancement on follow up on magnetic resonance imaging portended lesion regression.

CONCLUSION: Tumefactive demyelination may predict a more benign overall course and is susceptible to traditional immunomodulatory treatments.

Author List

Brod SA, Lindsey JW, Nelson F

Author

Staley A. Brod MD Professor in the Neurology department at Medical College of Wisconsin