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Regulators of G protein signaling in cardiovascular function during pregnancy. Physiol Genomics 2018 08 01;50(8):590-604

Date

04/28/2018

Pubmed ID

29702036

Pubmed Central ID

PMC6139632

DOI

10.1152/physiolgenomics.00037.2018

Scopus ID

2-s2.0-85056621405   17 Citations

Abstract

G protein-coupled receptor signaling mechanisms are implicated in many aspects of cardiovascular control, and dysfunction of such signaling mechanisms is commonly associated with disease states. Investigators have identified a large number of regulator of G protein signaling (RGS) proteins that variously contribute to the modulation of intracellular second-messenger signaling kinetics. These many RGS proteins each interact with a specific set of second-messenger cascades and receptor types and exhibit tissue-specific expression patterns. Increasing evidence supports the contribution of RGS proteins, or their loss, in the pathogenesis of cardiovascular dysfunctions. This review summarizes the current understanding of the functional contributions of RGS proteins, particularly within the B/R4 family, in cardiovascular disorders of pregnancy including gestational hypertension, uterine artery dysfunction, and preeclampsia.

Author List

Perschbacher KJ, Deng G, Fisher RA, Gibson-Corley KN, Santillan MK, Grobe JL

Author

Justin L. Grobe PhD Associate Professor in the Physiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Cardiovascular Physiological Phenomena
Female
Humans
Polymorphism, Single Nucleotide
Pregnancy
Protein Binding
RGS Proteins
Receptors, G-Protein-Coupled
Signal Transduction