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Control of Energy Expenditure by AgRP Neurons of the Arcuate Nucleus: Neurocircuitry, Signaling Pathways, and Angiotensin. Curr Hypertens Rep 2018 03 19;20(3):25

Date

03/21/2018

Pubmed ID

29556733

Pubmed Central ID

PMC5882211

DOI

10.1007/s11906-018-0824-8

Scopus ID

2-s2.0-85044249515   14 Citations

Abstract

PURPOSE OF REVIEW: Here, we review the current understanding of the functional neuroanatomy of neurons expressing Agouti-related peptide (AgRP) and the angiotensin 1A receptor (AT1A) within the arcuate nucleus (ARC) in the control of energy balance.

RECENT FINDINGS: The development and maintenance of obesity involves suppression of resting metabolic rate (RMR). RMR control is integrated via AgRP and proopiomelanocortin neurons within the ARC. Their projections to other hypothalamic and extrahypothalamic nuclei contribute to RMR control, though relatively little is known about the contributions of individual projections and the neurotransmitters involved. Recent studies highlight a role for AT1A, localized to AgRP neurons, but the specific function of AT1A within these cells remains unclear. AT1A functions within AgRP neurons to control RMR, but additional work is required to clarify its role within subpopulations of AgRP neurons projecting to distinct second-order nuclei, and the molecular mediators of its signaling within these cells.

Author List

Morselli LL, Claflin KE, Cui H, Grobe JL

Authors

Justin L. Grobe PhD Associate Professor in the Physiology department at Medical College of Wisconsin
Lisa Morselli MD, PhD Assistant Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Agouti-Related Protein
Angiotensins
Animals
Arcuate Nucleus of Hypothalamus
Energy Metabolism
Humans
Hypertension
Neurons
Obesity
Receptor, Angiotensin, Type 1
Signal Transduction