CD4+ T Cells Coexpressing CD134 (OX40) Harbor Significantly Increased Levels of Human Herpesvirus 6B DNA Following Umbilical Cord Blood Transplantation. J Infect Dis 2016 Dec 15;214(12):1911-1915
Date
10/06/2016Pubmed ID
27703035Pubmed Central ID
PMC5142091DOI
10.1093/infdis/jiw469Scopus ID
2-s2.0-85016033918 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
Human herpesvirus 6B (HHV-6B) commonly reactivates after umbilical cord blood transplantation (UCBT) and is associated with delayed engraftment, fever, rash, and central nervous system dysfunction. Recently, CD134 (OX40) has been implicated as a potential viral entry receptor. We evaluated CD4+CD134+/neg-lo and CD8+CD134+/neg-lo cells at day 28 after UCBT in 20 subjects with previously documented HHV-6 reactivation and persistent viremia. Analysis of CD4+CD134+ cells as compared to CD4+CD134neg-lo cells showed 0.308 versus 0.129 copies of HHV-6B/cell (P = .0002). CD8+CD134+/neg-lo cells contained little to no HHV-6B copies. Following UCBT, CD4+CD134+ cells harbor significantly increased levels of HHV-6B, suggesting that CD134 (OX40) may facilitate viral entry.
Author List
Pritchett JC, Green JS, Thomm AM, Knox KK, Verneris MR, Lund TCMESH terms used to index this publication - Major topics in bold
AdultCD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Child
Cohort Studies
DNA, Viral
Female
Fetal Blood
Herpesvirus 6, Human
Humans
Infant
Male
Middle Aged
Receptors, OX40
Roseolovirus Infections
Transplantation
Young Adult