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The Roles of Hippo Signaling Transducers Yap and Taz in Chromatin Remodeling. Cells 2019 05 24;8(5)

Date

05/30/2019

Pubmed ID

31137701

Pubmed Central ID

PMC6562424

DOI

10.3390/cells8050502

Abstract

Hippo signaling controls cellular processes that ultimately impact organogenesis and homeostasis. Consequently, disease states including cancer can emerge when signaling is deregulated. The major pathway transducers Yap and Taz require cofactors to impart transcriptional control over target genes. Research into Yap/Taz-mediated epigenetic modifications has revealed their association with chromatin-remodeling complex proteins as a means of altering chromatin structure, therefore affecting accessibility and activity of target genes. Specifically, Yap/Taz have been found to associate with factors of the GAGA, Ncoa6, Mediator, Switch/sucrose nonfermentable (SWI/SNF), and Nucleosome Remodeling and Deacetylase (NuRD) chromatin-remodeling complexes to alter the accessibility of target genes. This review highlights the different mechanisms by which Yap/Taz collaborate with other factors to modify DNA packing at specific loci to either activate or repress target gene transcription.

Author List

Hillmer RE, Link BA

Author

Brian A. Link PhD Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adaptor Proteins, Signal Transducing
Animals
Cell Cycle Proteins
Chromatin Assembly and Disassembly
DNA-Binding Proteins
Drosophila
Drosophila Proteins
Genes, Switch
Humans
Mi-2 Nucleosome Remodeling and Deacetylase Complex
Nuclear Proteins
Protein-Serine-Threonine Kinases
Trans-Activators
Transcription Factors
jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0