The Roles of Hippo Signaling Transducers Yap and Taz in Chromatin Remodeling. Cells 2019 May 24;8(5)
Date
05/30/2019Pubmed ID
31137701Pubmed Central ID
PMC6562424DOI
10.3390/cells8050502Scopus ID
2-s2.0-85076223119 (requires institutional sign-in at Scopus site) 52 CitationsAbstract
Hippo signaling controls cellular processes that ultimately impact organogenesis and homeostasis. Consequently, disease states including cancer can emerge when signaling is deregulated. The major pathway transducers Yap and Taz require cofactors to impart transcriptional control over target genes. Research into Yap/Taz-mediated epigenetic modifications has revealed their association with chromatin-remodeling complex proteins as a means of altering chromatin structure, therefore affecting accessibility and activity of target genes. Specifically, Yap/Taz have been found to associate with factors of the GAGA, Ncoa6, Mediator, Switch/sucrose nonfermentable (SWI/SNF), and Nucleosome Remodeling and Deacetylase (NuRD) chromatin-remodeling complexes to alter the accessibility of target genes. This review highlights the different mechanisms by which Yap/Taz collaborate with other factors to modify DNA packing at specific loci to either activate or repress target gene transcription.
Author List
Hillmer RE, Link BAAuthors
Ryan Edward Hillmer PhD Assistant Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinBrian A. Link PhD Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Adaptor Proteins, Signal TransducingAnimals
Cell Cycle Proteins
Chromatin Assembly and Disassembly
DNA-Binding Proteins
Drosophila
Drosophila Proteins
Genes, Switch
Humans
Mi-2 Nucleosome Remodeling and Deacetylase Complex
Nuclear Proteins
Signal Transduction
Trans-Activators
Transcription Factors
