Faculty Collaboration Database

Ca²⁺ Signaling and Regeneration. Cold Spring Harb Perspect Biol 2019 Nov 01;11(11)

Date

07/17/2019

Pubmed ID

31308144

Pubmed Central ID

PMC6824241

DOI

10.1101/cshperspect.a035485

Scopus ID

2-s2.0-85074378851 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

Regeneration is the process by which lost or damaged tissue is replaced in adult organisms. Some organisms exhibit robust regenerative capabilities, while others, including humans, do not. Understanding the molecular principles governing the regenerative malleability of different organisms is of fundamental biological interest. Further, this problem has clear impact for the field of "regenerative medicine," which aspires to understand how human cells, tissues, and organs may be restored to normal function in scenarios of disease, damage, or age-related decline. This review will focus on the planarian flatworm as a powerful model system for studying the role of Ca²⁺ signals in regeneration. These invertebrate animals display an astounding innate regenerative capacity capable of regenerating complete organisms from tiny, excised fragments. New knowledge and methodological capabilities in this system highlight the potential for studying the role of Ca²⁺ signaling at multiple stages of the regenerative blueprint that controls stem cell behavior in vivo.

Author List

Marchant JS

Author

Jonathan S. Marchant PhD Chair, Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Calcium Signaling
Humans
Models, Biological
Planarians
Protein Binding
Regeneration