Faculty Collaboration Database

Inhibition by sugars of Candida albicans adherence to human buccal mucosal cells and corneocytes in vitro. Infect Immun 1984 Dec;46(3):831-4

Date

12/01/1984

Pubmed ID

6389365

Pubmed Central ID

PMC261621

DOI

10.1128/iai.46.3.831-834.1984

Scopus ID

2-s2.0-0021680359 (requires institutional sign-in at Scopus site)   36 Citations

Abstract

The adherence and inhibition of adherence of Candida albicans to epithelial cells was studied for human cells obtained from skin (corneocytes) and buccal mucosa. The yeast adhered to both kinds of cells, although in somewhat greater numbers to buccal mucosal cells. Adherence to the cells of different individuals was variable, but the ratios of values for the two kinds of cells from a single subject were quite constant. Inhibition of adherence was produced by several sugars, including the aminosugars mannosamine, glucosamine, and galactosamine. The pattern of inhibition produced by the sugars was similar for the two types of cells. Pretreatment of the yeast with mannosamine, followed by dilution to a subinhibitory concentration, produced some inhibition of yeast-buccal mucosal cell attachment, indicating some direct interaction between the sugar and the fungal cell. These data suggest that the mechanisms whereby C. albicans attaches to corneocytes and to buccal mucosal cells are probably similar.

Author List

Collins-Lech C, Kalbfleisch JH, Franson TR, Sohnle PG

Author

Peter G. Sohnle MS, MD Emeritus Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adhesiveness
Candida albicans
Carbohydrates
Humans
Mouth Mucosa
Skin