Class-specific antibodies in young and aged humans against organisms producing superficial fungal infections. Br J Dermatol 1983 Jan;108(1):69-76
Date
01/01/1983Pubmed ID
6336945DOI
10.1111/j.1365-2133.1983.tb04580.xScopus ID
2-s2.0-0020685944 (requires institutional sign-in at Scopus site) 22 CitationsAbstract
Class-specific antibodies (IgG, IgA and IgM) against Candida albicans, Pityrosporum orbiculare and Trichophyton rubrum were measured in the serum from twenty-one young subjects (aged 23-44) and twenty elderly subjects (aged 70-88) who did not have a history of significant superficial fungal infections. We found that (a) antibody to all three organisms was present in all subjects in both groups, (b) except for a reduced level of IgM antibody against P. orbiculare, the elderly subjects demonstrated humoral responses in these assays similar to those of the young subjects, (c) IgA antibody was present in higher amounts against C. albicans that against P. orbiculare or T. rubrum in both groups, and (d) the proportion of IgM antibody against T. rubrum was higher than that against the other two organisms. These findings suggest that the ecology of these three organisms with respect to the normal human host may be reflected in the serological responses against them.
Author List
Sohnle PG, Collins-Lech C, Huhta KEMESH terms used to index this publication - Major topics in bold
AdultAge Factors
Aged
Antibodies, Fungal
Antibody Specificity
Candida albicans
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Malassezia
Male
Trichophyton
