GB virus type C infection polarizes T-cell cytokine gene expression toward a Th1 cytokine profile via NS5A protein expression. J Infect Dis 2012 Jul 01;206(1):69-72
Date
04/27/2012Pubmed ID
22535999Pubmed Central ID
PMC3415935DOI
10.1093/infdis/jis312Scopus ID
2-s2.0-84857999729 (requires institutional sign-in at Scopus site) 13 CitationsAbstract
Human immunodeficiency virus (HIV) disease progression is associated with a helper T cell 1 (Th1) to helper T cell 2 (Th2) cytokine profile switch. Persistent GB virus type C (GBV-C) infection is associated with survival and a serum Th1 cytokine profile in HIV-infected individuals. We found that GBV-C infection increased gene expression of Th1 cytokines and decreased Th2 cytokine expression in peripheral blood mononuclear cells. Furthermore, expression of GBV-C NS5A protein in a CD4(+) cell line resulted in upregulation of Th1 cytokines (tumor necrosis factor α) and downregulation of Th2 cytokines (interleukin 4, interleukin 5, interleukin 10, interleukin 13). GBV-C-induced modulation in T-cell cytokines may contribute to the beneficial effect of GBV-C in HIV-infected individuals.
Author List
Rydze RT, Xiang J, McLinden JH, Stapleton JTAuthor
Robert Rydze MD Assistant Professor in the Obstetrics and Gynecology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
CD4-Positive T-LymphocytesCytokines
Down-Regulation
Flaviviridae Infections
GB virus C
Gene Expression
HIV Infections
HIV-1
Hepatitis, Viral, Human
Humans
Leukocytes, Mononuclear
Phosphoproteins
Th1 Cells
Th2 Cells
Up-Regulation
Viral Nonstructural Proteins