Faculty Collaboration Database

Prevalence and predictors of coronary artery disease in adults with Kawasaki disease. Cardiol Young 2015 Aug;25(6):1124-9

Date

10/24/2014

Pubmed ID

25338916

DOI

10.1017/S1047951114001759

Scopus ID

2-s2.0-84945436062 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

BACKGROUND: Accelerated coronary atherosclerosis in patients with Kawasaki disease, in conjunction with coronary artery aneurysm and stenosis that characterise this disease, are potential risk factors for developing coronary artery disease in young adults. We aimed to determine the prevalence and predictors of coronary artery disease in adult patients with Kawasaki disease.

METHODS: All patients aged 18-55 years of age diagnosed with Kawasaki disease were sampled from Nationwide Inpatient Sample database using International Classification of Diseases 9th revision (ICD 9 code 446.1) from 2009 to 2010. Demographics, prevalence of coronary artery disease, and other traditional risk factors in adult patients with Kawasaki disease were analysed using ICD 9 codes.

RESULTS: The prevalence of Kawasaki disease among adults was 0.0005% (n=215) of all in-hospital admissions in United States. The mean age was 27.3 years with women (27.6 years) older than men (27.1 years). Traditional risk factors were hypertension (21%), hyperlipidaemia (15.6%), diabetes (11.5%), tobacco use (8.8%), and obesity (8.8%), with no significant difference between men and women. Coronary artery disease (32.4%), however, was more prevalent in men (44.7%) than in women (12.1%; p=0.03). In multivariate regression analysis, after adjusting for demographics and traditional risk factors, hypertension (OR=13.2, p=0.03) was an independent risk factor of coronary artery disease.

CONCLUSION: There was increased preponderance of coronary artery disease in men with Kawasaki disease. On multivariate analysis, hypertension was found to be the only independent predictor of coronary artery disease in this population after adjusting for other risk factors.

Author List

Garg J, Krishnamoorthy P, Palaniswamy C, Paudel R, Chatterjee S, Ahmad H, Snyder C

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Coronary Artery Disease
Diabetes Mellitus
Female
Humans
Hyperlipidemias
Hypertension
Logistic Models
Male
Middle Aged
Mucocutaneous Lymph Node Syndrome
Multivariate Analysis
Obesity
Prognosis
Retrospective Studies
Risk Factors
Sex Characteristics
Tobacco Use
United States
Young Adult