Faculty Collaboration Database

Suppression of adrenal mineralocorticoid production in prehypertensive young adult men. J Clin Endocrinol Metab 1983 Jan;56(1):87-92

Date

01/01/1983

Pubmed ID

6292257

DOI

10.1210/jcem-56-1-87

Scopus ID

2-s2.0-84995969781 (requires institutional sign-in at Scopus site)   6 Citations

Abstract

We assessed the renin-aldosterone axis in response to treadmill exercise and adrenal steroidogenesis after graded ACTH infusions in two groups, each composed of nine young adult men from Bourbon County, Kentucky, from the upper and lower deciles of the blood pressure distribution. Those from the upper decile with relatively higher blood pressures, termed prehypertensive, had significantly lower plasma aldosterone and 18-hydroxycorticosterone concentrations after graded ACTH than those with relatively lower pressures, and had significantly lower urinary potassium excretions. Renin and aldosterone responses to exercise were also significantly blunted in the prehypertensive subjects. No differences were found in plasma cortisol, deoxycortisol, deoxycorticosterone, corticosterone, or dehydroepiandrosterone sulfate, although dehydroepiandrosterone was higher at one infusion rate in prehypertensives. These findings suggest that the adrenal mineralocorticoid pathway and the renin-aldosterone axis are suppressed in prehypertensive young males perhaps as an appropriate feedback response to their higher blood pressures.

Author List

Guthrie GP Jr, Kotchen TA, Kotchen JM

MESH terms used to index this publication - Major topics in bold

18-Hydroxycorticosterone
Adrenal Cortex Hormones
Adrenocorticotropic Hormone
Adult
Aldosterone
Dehydroepiandrosterone
Humans
Hypertension
Male
Physical Exertion
Potassium
Renin