Diabetic nephropathy in adolescence: appearance during improved glycemic control. Pediatrics 1983 May;71(5):824-9
Date
05/01/1983Pubmed ID
6340051Scopus ID
2-s2.0-0020585028 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
Two girls, aged 15 and 14 years, with poorly controlled insulin-dependent diabetes (IDD) of 9 and 7 years duration, respectively, developed overt and persistent proteinuria shortly after rapid increases in insulin therapy and improved glycemic control. Renal biopsies showed diffuse diabetic glomerulosclerosis. Both patients maintained normal or increased creatinine clearances. Direct ophthalmoscopy and fluorescein retinal angiography demonstrated nonproliferative diabetic retinopathy in the first patient, which deteriorated after 6 weeks of strict metabolic control; the second patient had normal retinas. The appearance of clinical proteinuria during this brief period of good glycemic control suggests that the latter may have unmasked a preexisting condition. Possible pathophysiologic mechanisms initiating the proteinuria in these patients are reviewed.
Author List
Ellis D, Avner ED, Transue D, Yunis EJ, Drash AL, Becker DJAuthor
Ellis D. Avner MD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentDiabetes Mellitus, Type 1
Diabetic Nephropathies
Diabetic Retinopathy
Female
Humans
Insulin
Kidney
Proteinuria
