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Subependymal giant cell astrocytomas in children. Pediatr Neurosurg 1994;20(4):233-9

Date

01/01/1994

Pubmed ID

8043461

DOI

10.1159/000120796

Scopus ID

2-s2.0-0028246540 (requires institutional sign-in at Scopus site)   72 Citations

Abstract

Between 1977 and 1991, at the Children's Hospital of Philadelphia, 10 patients, 5-16 years of age, were diagnosed as having subependymal giant cell astrocytomas. These patients accounted for 1.4% of all pediatric brain tumors seen during that time interval. One patient received a course of radiation therapy, which was ineffective in preventing tumor growth. All underwent surgical resections with the goal being maximal tumor debulking, if not complete resection. In 6 patients this was accomplished by the frontal transventricular route and, in the more recent patients, surgery was performed using a transcallosal approach. There were 2 perioperative deaths, and 2 other patients died later of causes unrelated to tumor progression. The remaining 6 patients remain alive and stable at a mean of 6.7 years of follow-up (range 1.8-12.4). None of these patients has received additional radiation therapy. Two patients have no other evidence of tuberous sclerosis. The use of modern radiographic and surgical techniques has made the treatment of this disease safer than in the past.

Author List

Sinson G, Sutton LN, Yachnis AT, Duhaime AC, Schut L

Author

Grant P. Sinson MD Associate Professor in the Neurosurgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Astrocytoma
Brain Neoplasms
Child
Craniotomy
Ependyma
Female
Humans
Hydrocephalus
Magnetic Resonance Imaging
Male
Survival Rate
Tomography, X-Ray Computed
Treatment Outcome
Tuberous Sclerosis
Ventriculoperitoneal Shunt