Early Axonal Area Measurement Predicts Early Nerve Regeneration Outcomes. J Reconstr Microsurg 2016 Mar;32(3):222-5
Date
12/05/2015Pubmed ID
26636887DOI
10.1055/s-0035-1568155Scopus ID
2-s2.0-84960086284 (requires institutional sign-in at Scopus site)Abstract
BACKGROUND: Study of peripheral nerve injury and regeneration in laboratory animals can be time consuming and expensive. This study determines if it is possible to reduce time and cost for a peripheral nerve regeneration study.
PURPOSE: The purpose of this study was to determine if nerve axonal area (NXA) or nerve fiber counting (NFC) correlates with compound muscle action potential (CMAP) recovery which is known to predict functional muscular recovery in the early stage of nerve regeneration.
METHODS: In this study, six rats had a crush injury of the sciatic nerve without treatment. These rats were evaluated at 4 weeks of recovery with the following assessments: CMAP readings from the extensor digitorum longus, NXA measurement, and NFC.
RESULTS: NXA correlated with CMAP; NFC did not correlate with CMAP.
CONCLUSION: NFC is not a reliable method for predicting muscular recovery in the early stages. NXA is a dependable assessment for muscular recovery in the early stages of nerve regeneration. Using NXA measurement can predict later electrophysiological and functional recovery. Using NXA with CMAP measurement for nerve injury, repair, and treatment in the animal study can save cost and time.
Author List
Neilson M, Yan Y, Zhang LL, Wang Z, Agresti M, Matloub H, Yan JGAuthor
Hani S. Matloub MD Professor in the Plastic Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Action PotentialsAnimals
Disease Models, Animal
Male
Nerve Crush
Nerve Fibers
Nerve Regeneration
Peripheral Nerve Injuries
Rats
Rats, Sprague-Dawley
Recovery of Function
Sciatic Nerve
