Continuous 5-fluorouracil (5FU) infusion in carcinoma of the pancreas: a phase II study. Am J Med Sci 1988 Feb;295(2):91-3
Date
02/01/1988Pubmed ID
3344760DOI
10.1097/00000441-198802000-00001Scopus ID
2-s2.0-0023880296 (requires institutional sign-in at Scopus site) 80 CitationsAbstract
UNLABELLED: Sixteen patients with metastatic carcinoma of the pancreas were treated with continuous ambulatory 5-Fluorouracil (5FU) infusion (200-300 mg/m2/day) through a chronic indwelling central venous catheter. Twelve of sixteen patients (75%) had two or more sites of disease, and eleven of sixteen (69%) had liver metastases. Five patients had previous chemotherapy.
RESULTS: partial remission, 3/16 (19%); stable disease, 8/16 (50%); and progressive disease, 5/16 (31%). Improvement in ECOG performance status was observed in 2/3 responding and 6/8 stable disease patients, respectively. Toxicities included hand-foot syndrome, mucositis, diarrhea, and cerebellar ataxia, which required treatment interruption in 9/16 patients (56%). No myelosuppression or catheter related problems were seen. The authors conclude that continuous infusion 5FU is a potentially efficacious palliative therapy in the management of carcinoma of the pancreas.
Author List
Hansen R, Quebbeman E, Ritch P, Chitambar C, Anderson TMESH terms used to index this publication - Major topics in bold
AdultAged
Drug Evaluation
Female
Fluorouracil
Humans
Male
Middle Aged
Pancreatic Neoplasms