Survival in Alzheimer's disease is shorter in women carrying heterozygosity at codon 129 of the PRNP gene and no APOE epsilon 4 allele. Dement Geriatr Cogn Disord 2008;25(4):354-8
Date
03/12/2008Pubmed ID
18332630DOI
10.1159/000119730Scopus ID
2-s2.0-42449089010 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
We assessed the role of the APOE genotype and prion protein polymorphism at codon 129 in predicting the clinical duration of 92 neuropathologically confirmed sporadic Alzheimer's disease patients. Analyses of survival showed that the absence of the APOE epsilon 4 allele in heterozygous codon 129 PRNP carriers is a negative predictor of survival. When this subgroup of patients was stratified by sex, the effect of APOE was observed in women, but not in men.
Author List
Giannattasio C, Poleggi A, Puopolo M, Pocchiari M, Antuono P, Dal Forno G, Wekstein DR, Matera MG, Seripa D, Acciarri A, Bizzarro A, Lauria A, Masullo CAuthor
Piero G. Antuono MD Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedAged, 80 and over
Alleles
Alzheimer Disease
Apolipoprotein E4
Female
Genetic Predisposition to Disease
Heterozygote
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Polymorphism, Genetic
Prion Proteins
Prions
Risk Factors
