Medical College of Wisconsin
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Choline acetyltransferase and acetylcholinesterase abnormalities in senile dementia: importance of biochemical measurements in human post-mortem brain specimens. Ital J Neurol Sci 1980 Mar;1(2):75-83

Date

03/01/1980

Pubmed ID

7040296

DOI

10.1007/BF02336848

Scopus ID

2-s2.0-0018640214 (requires institutional sign-in at Scopus site)   7 Citations

Abstract

Choline acetyltransferase and acetylcholinesterase have been assessed in human aging brains, in demented and agonal states. Choline acetyl transferase decreased during aging in normal brain when measured in the cerebral cortex. Choline acetyltransferase was also reduced in several other brain areas in patients with Alzheimer's disease and in one patient with Creutzfeldt-Jakob disease. Choline acetyltransferase was also reduced in bronchopneumonia and in some terminal conditions. On the contrary, the activity was not reduced in patients who died after cerebrovascular accidents. Acetylcholine esterase, although it followed the general trend of choline acetyltransferase, did not yield significant results.

Author List

Sorbi S, Antuono P, Amaducci L

Author

Piero G. Antuono MD Professor in the Neurology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Acetylcholinesterase
Aged
Alzheimer Disease
Brain
Bronchopneumonia
Cerebrovascular Disorders
Choline O-Acetyltransferase
Coma
Creutzfeldt-Jakob Syndrome
Dementia
Humans
Middle Aged
Postmortem Changes