Faculty Collaboration Database

Immunoglobulins and other modalities for the prevention and treatment of enteric viral infections. J Clin Immunol 1990 Nov;10(6 Suppl):80S-86S; discussion 86S-87S

Date

11/01/1990

Pubmed ID

2081794

DOI

10.1007/BF00918695

Scopus ID

2-s2.0-0025610319 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

Viral infections of the gastrointestinal tract constitute a major health problem during the first years of life. In addition to causing acute diarrhea, rotaviruses and other enteric viruses may be involved in the pathogenesis of necrotizing enterocolitis and other neonatal enteric diseases. There are several potential methods for the prevention and treatment of gastrointestinal viral infections. Antiviral immune globulins, administered by the parenteral or oral route, might prove useful for the inhibition of intestinal viral replication. Alternatively, specific glycoprotein inhibitors of viral-cell binding might be used to prevent the productive infection of intestinal epithelial cells. In addition, since many enteric viruses require proteolytic enzymes for protein cleavage, protease inhibitors may prove to be effective agents for the inhibition of intestinal viral replication. At this point in time, these methods have proven useful for the inhibition of rotavirus infection in experimental animals. The successful application of these and other methods for the prevention of enteric infections in humans might substantially reduce the morbidity and mortality associated with enteric diseases.

Author List

Yolken R, Kinney J, Wilde J, Willoughby R, Eiden J

Author

Rodney E. Willoughby MD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Gastrointestinal Diseases
Humans
Immunization, Passive
Mucins
Protease Inhibitors
Rotavirus Infections
United States
Virus Diseases