Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course. Cell Host Microbe 2018 Oct 10;24(4):600-610.e4
Date
10/12/2018Pubmed ID
30308161Pubmed Central ID
PMC6277984DOI
10.1016/j.chom.2018.09.009Scopus ID
2-s2.0-85054102370 (requires institutional sign-in at Scopus site) 154 CitationsAbstract
Evaluating progression risk and determining optimal therapy for ulcerative colitis (UC) is challenging as many patients exhibit incomplete responses to treatment. As part of the PROTECT (Predicting Response to Standardized Colitis Therapy) Study, we evaluated the role of the gut microbiome in disease course for 405 pediatric, new-onset, treatment-naive UC patients. Patients were monitored for 1 year upon treatment initiation, and microbial taxonomic composition was analyzed from fecal samples and rectal biopsies. Depletion of core gut microbes and expansion of bacteria typical of the oral cavity were associated with baseline disease severity. Remission and refractory disease were linked to species-specific temporal changes that may be implicative of therapy efficacy, and a pronounced increase in microbiome variability was observed prior to colectomy. Finally, microbial associations with disease-associated serological markers suggest host-microbial interactions in UC. These insights will help improve existing treatments and develop therapeutic approaches guiding optimal medical care.
Author List
Schirmer M, Denson L, Vlamakis H, Franzosa EA, Thomas S, Gotman NM, Rufo P, Baker SS, Sauer C, Markowitz J, Pfefferkorn M, Oliva-Hemker M, Rosh J, Otley A, Boyle B, Mack D, Baldassano R, Keljo D, LeLeiko N, Heyman M, Griffiths A, Patel AS, Noe J, Kugathasan S, Walters T, Huttenhower C, Hyams J, Xavier RJAuthor
Joshua D. Noe MD Associate Dean, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdrenal Cortex Hormones
Anti-Inflammatory Agents, Non-Steroidal
Child
Child, Preschool
Clostridiales
Cohort Studies
Colectomy
Colitis, Ulcerative
Disease Progression
Feces
Female
Gastrointestinal Microbiome
Humans
Leukocyte L1 Antigen Complex
Longitudinal Studies
Male
Mesalamine
Time Factors
