A state-of-the-art review and guidelines for tumor treating fields treatment planning and patient follow-up in glioblastoma. CNS Oncol 2017 Jan;6(1):29-43
Date
09/16/2016Pubmed ID
27628854Pubmed Central ID
PMC6027938DOI
10.2217/cns-2016-0032Scopus ID
2-s2.0-85050579311 29 CitationsAbstract
Tumor treating fields (TTFields) are an integral treatment modality in the management of glioblastoma and extend overall survival when combined with maintenance temozolomide in newly diagnosed patients. Complexities exist regarding correct selection of imaging sequences with which to perform TTFields treatment planning. Guidelines are warranted first, to facilitate treatment planning standardization across medical disciplines and institutions, to ensure optimal TTFields delivery to the tumor and peritumoral brain zone while maximizing patient safety, and also to mitigate the risk of premature cessation of a potentially beneficial treatment. This summary guideline outlines methods for starting patients on TTFields, for monitoring patient response to therapy and provides a framework for evaluating when therapy should be re-planned, based on the extent of sequential imaging changes.
Author List
Trusheim J, Dunbar E, Battiste J, Iwamoto F, Mohile N, Damek D, Bota DA, Connelly JAuthor
Jennifer M. Connelly MD Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AlgorithmsAntineoplastic Agents, Alkylating
Brain Neoplasms
Combined Modality Therapy
Dacarbazine
Female
Follow-Up Studies
Glioblastoma
Humans
Magnetic Field Therapy
Magnetic Resonance Imaging
Male
Practice Guidelines as Topic
