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A state-of-the-art review and guidelines for tumor treating fields treatment planning and patient follow-up in glioblastoma. CNS Oncol 2017 Jan;6(1):29-43

Date

09/16/2016

Pubmed ID

27628854

Pubmed Central ID

PMC6027938

DOI

10.2217/cns-2016-0032

Scopus ID

2-s2.0-85050579311   29 Citations

Abstract

Tumor treating fields (TTFields) are an integral treatment modality in the management of glioblastoma and extend overall survival when combined with maintenance temozolomide in newly diagnosed patients. Complexities exist regarding correct selection of imaging sequences with which to perform TTFields treatment planning. Guidelines are warranted first, to facilitate treatment planning standardization across medical disciplines and institutions, to ensure optimal TTFields delivery to the tumor and peritumoral brain zone while maximizing patient safety, and also to mitigate the risk of premature cessation of a potentially beneficial treatment. This summary guideline outlines methods for starting patients on TTFields, for monitoring patient response to therapy and provides a framework for evaluating when therapy should be re-planned, based on the extent of sequential imaging changes.

Author List

Trusheim J, Dunbar E, Battiste J, Iwamoto F, Mohile N, Damek D, Bota DA, Connelly J

Author

Jennifer M. Connelly MD Professor in the Neurology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Algorithms
Antineoplastic Agents, Alkylating
Brain Neoplasms
Combined Modality Therapy
Dacarbazine
Female
Follow-Up Studies
Glioblastoma
Humans
Magnetic Field Therapy
Magnetic Resonance Imaging
Male
Practice Guidelines as Topic