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Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors. Immunity 2000 Jul;13(1):25-35

Date

08/10/2000

Pubmed ID

10933392

DOI

10.1016/s1074-7613(00)00005-4

Scopus ID

2-s2.0-0033624638   383 Citations

Abstract

Many receptors activate phospholipase Cgamma1 or -gamma2. To assess the role of PLCgamma2, we derived enzyme-deficient mice. The mice are viable but have decreased mature B cells, a block in pro-B cell differentiation, and B1 B cell deficiency. IgM receptor-induced Ca2+ flux and proliferation to B cell mitogens are absent. IgM, IgG2a, and IgG3 levels are reduced, and T cell-independent antibody production is absent. The similarity to Btk- or Blnk-deficient mice demonstrates that PLCgamma2 is downstream in Btk/Blnk signaling. FcRgamma signaling is also defective, resulting in a loss of collagen-induced platelet aggregation, mast cell FcepsilonR function, and NK cell FcgammaRIII and 2B4 function. The results define a signal transduction pathway broadly utilized by immunoglobulin superfamily receptors.

Author List

Wang D, Feng J, Wen R, Marine JC, Sangster MY, Parganas E, Hoffmeyer A, Jackson CW, Cleveland JL, Murray PJ, Ihle JN

Author

Demin Wang PhD Assistant Professor in the Microbiology and Immunology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adaptor Proteins, Signal Transducing
Animals
B-Lymphocytes
Blood Platelets
Carrier Proteins
Hematopoiesis
Isoenzymes
Mice
Mice, Inbred C57BL
Mice, Knockout
Phospholipase C gamma
Phosphoproteins
Protein-Tyrosine Kinases
Receptors, Antigen, B-Cell
Receptors, IgG
Type C Phospholipases
jenkins-FCD Prod-469 c3fc8ab87196149f9b23743c01b947d47e7319e5