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Jak2 is essential for signaling through a variety of cytokine receptors. Cell 1998 May 01;93(3):385-95

Date

05/20/1998

Pubmed ID

9590173

DOI

10.1016/s0092-8674(00)81167-8

Scopus ID

2-s2.0-0032076542   832 Citations

Abstract

A variety of cytokines activate receptor-associated members of the Janus family of protein tyrosine kinases (Jaks). To assess the role of Jak2, we have derived Jak2-deficient mice. The mutation causes an embryonic lethality due to the absence of definitive erythropoiesis. Fetal liver myeloid progenitors, although present based on the expression of lineage specific markers, fail to respond to erythropoietin, thrombopoietin, interleukin-3 (IL-3), or granulocyte/macrophage colony-stimulating factor. In contrast, the response to granulocyte specific colony-stimulating factor is unaffected. Jak2-deficient fibroblasts failed to respond to interferon gamma (IFNgamma), although the responses to IFNalpha/beta and IL-6 were unaffected. Lastly, reconstitution experiments demonstrate that Jak2 is not required for the generation of lymphoid progenitors, their amplification, or functional differentiation. Therefore, Jak2 plays a critical, nonredundant role in the function of a specific group of cytokines receptors.

Author List

Parganas E, Wang D, Stravopodis D, Topham DJ, Marine JC, Teglund S, Vanin EF, Bodner S, Colamonici OR, van Deursen JM, Grosveld G, Ihle JN

Author

Demin Wang PhD Assistant Professor in the Microbiology and Immunology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
B-Lymphocytes
Cell Differentiation
Colony-Stimulating Factors
Cytokines
DNA-Binding Proteins
Erythropoiesis
Fibroblasts
Hematopoietic Stem Cells
Interferon Regulatory Factor-1
Janus Kinase 2
Liver
Mice
Mice, Knockout
Phenotype
Phosphoproteins
Phosphorylation
Protein-Tyrosine Kinases
Proto-Oncogene Proteins
RNA, Messenger
Receptors, Cytokine
Signal Transduction
T-Lymphocytes
Thrombopoietin
Thymus Gland
Tyrosine
jenkins-FCD Prod-469 c3fc8ab87196149f9b23743c01b947d47e7319e5