Delineating potential epileptogenic areas utilizing resting functional magnetic resonance imaging (fMRI) in epilepsy patients. Neurocase 2016 Aug;22(4):362-8
Date
07/01/2016Pubmed ID
27362339Pubmed Central ID
PMC4979575DOI
10.1080/13554794.2016.1195845Scopus ID
2-s2.0-84976562449 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
Seizure localization includes neuroimaging like electroencephalogram, and magnetic resonance imaging (MRI) with limited ability to characterize the epileptogenic network. Temporal clustering analysis (TCA) characterizes epileptogenic network congruent with interictal epileptiform discharges by clustering together voxels with transient signals. We generated epileptogenic areas for 12 of 13 epilepsy patients with TCA, congruent with different areas of seizure onset. Resting functional MRI (fMRI) scans are noninvasive, and can be acquired quickly, in patients with different levels of severity and function. Analyzing resting fMRI data using TCA is quick and can complement clinical methods to characterize the epileptogenic network.
Author List
Pizarro R, Nair V, Meier T, Holdsworth R, Tunnell E, Rutecki P, Sillay K, Meyerand ME, Prabhakaran VAuthor
Timothy B. Meier PhD Associate Professor in the Neurosurgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultElectroencephalography
Epilepsy
Functional Neuroimaging
Hippocampus
Humans
Magnetic Resonance Imaging
Temporal Lobe