Assessment of the effects of ciprofloxacin and nalidixic acid on cerebral blood flow and metabolism in healthy subjects by positron emission tomography. Pharmacotherapy 1994;14(2):153-61
Date
03/01/1994Pubmed ID
8197033DOI
10.1002/j.1875-9114.1994.tb02802.xScopus ID
2-s2.0-0028316628 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
STUDY OBJECTIVES: The mechanism by which the fluorinated quinolones produce central nervous system effects is unknown. Using positron emission tomography (PET), we evaluated the effects of two quinolones on brain blood flow as well as on oxygen and glucose metabolism. These determinations were done in conjunction with ophthalmologic and neuro-ophthalmologic testing.
DESIGN: Randomized, double-blind, placebo-controlled, 7-day course of ciprofloxacin 750 mg (C750) or 500 mg (C500) every 12 hours, or nalidixic acid (NA) 1 g every 6 hours.
POPULATION: Twenty-four healthy male volunteers, six in each treatment arm.
RESULTS: [table: see text]
CONCLUSIONS: Compared with baseline values, NA significantly reduced brain glucose uptake, whereas C500, C750, and placebo produced no detectable effect. No compound significantly altered brain blood flow or oxygen metabolism compared with baseline or other treatments. No significant effect on electroretinographic, electro-oculographic, or other neuro-ophthalmologic tests was observed.
Author List
Bednarczyk EM, Adler LP, Remler B, Goyer P, Wiznitzer M, Leisure GP, Little D, Miraldi FAuthor
Bernd F. Remler MD Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Animals
Brain
Cerebrovascular Circulation
Ciprofloxacin
Double-Blind Method
Drug Administration Schedule
Electrooculography
Electroretinography
Glucose
Humans
Male
Nalidixic Acid
Oxygen
Tomography, Emission-Computed
Vision, Ocular
