Expression of elongation factor-1 gamma-related sequence in human pancreatic cancer. Pancreas 1992;7(2):144-52
Date
01/01/1992Pubmed ID
1372736DOI
10.1097/00006676-199203000-00003Scopus ID
2-s2.0-0026505436 (requires institutional sign-in at Scopus site) 53 CitationsAbstract
A cDNA clone designated pPDC-1 was isolated from a cDNA library prepared against poly(A+)RNA isolated from the human pancreatic adenocarcinoma cell line, Capan-2. The cDNA corresponds to a 1.7-kilobase mRNA that is expressed at higher levels in seven of nine pancreatic tumors than in their corresponding normal tissues. It is also expressed in normal human kidney, intestine, pancreas, stomach, placenta, lung, brain, spleen, and liver. A computer search of the Intelligenetics System of all available nucleotide sequences revealed a 60% homology between the nucleotide sequence of the pPDC-1 cDNA and that of elongation factor-1 gamma from Artemia. The deduced amino acid sequence shared 53% identity with the amino acid sequence for the Artemia elongation factor-1 gamma.
Author List
Lew Y, Jones DV, Mars WM, Evans D, Byrd D, Frazier MLAuthor
Douglas B. Evans MD Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedAmino Acid Sequence
Base Sequence
Cloning, Molecular
DNA
Female
Gene Expression
Humans
Male
Middle Aged
Molecular Sequence Data
Pancreatic Neoplasms
Peptide Elongation Factor 1
Peptide Elongation Factors
RNA
