Radial artery tonometry demonstrates arterial stiffness in children with type 1 diabetes. Diabetes Care 2004 Dec;27(12):2911-7
Date
11/25/2004Pubmed ID
15562206DOI
10.2337/diacare.27.12.2911Scopus ID
2-s2.0-9444237926 (requires institutional sign-in at Scopus site) 140 CitationsAbstract
OBJECTIVE: To determine if children with type 1 diabetes have increased arterial stiffness by estimating augmentation index with the simple noninvasive technique of radial artery tonometry.
RESEARCH DESIGN AND METHODS: We studied 98 type 1 diabetic children and 57 healthy control subjects, ages 10-18 years, matched for age, sex, race, and BMI, generating 43 matched pairs. Radial artery tonometry was performed, and blood was collected for analysis of fasting lipids, HbA1c, glucose, and cytokines in all children.
RESULTS: Children with diabetes had a significantly higher augmentation index corrected to a heart rate of 75 (AI75) than their matched control subjects. Mean AI75 in type 1 diabetic subjects was 1.11 +/- 10.15 versus -3.32 +/- 10.36 in control subjects. The case-control difference was 5.20 +/- 11.02 (P=0.0031).
CONCLUSIONS: Children with type 1 diabetes have increased arterial stiffness compared with healthy control subjects. Radial artery tonometry is a simple noninvasive technique that could be added to the armamentarium of tests used to provide cardiovascular risk stratification in children with type 1 diabetes.
Author List
Haller MJ, Samyn M, Nichols WW, Brusko T, Wasserfall C, Schwartz RF, Atkinson M, Shuster JJ, Pierce GL, Silverstein JHAuthor
Margaret Mary Samyn MD, MBA Assistant Dean, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentBody Mass Index
Child
Diabetes Mellitus, Type 1
Diabetic Angiopathies
Female
Humans
Male
Manometry
Peripheral Vascular Diseases
Radial Artery
Reference Values
