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Tissue plasminogen activator reduces brain injury in a rabbit model of thromboembolic stroke. Stroke 1990 Dec;21(12):1705-9

Date

12/01/1990

Pubmed ID

2124736

DOI

10.1161/01.str.21.12.1705

Scopus ID

2-s2.0-0025687328 (requires institutional sign-in at Scopus site)   49 Citations

Abstract

Tissue plasminogen activator is an endogenous fibrin-specific serine protease with potent thrombolytic activity. We investigated the efficacy of tissue plasminogen activator in reducing cerebral infarct size after thromboembolic stroke in a rabbit model. Seventeen rabbits were randomized to receive either tissue plasminogen activator (2.5 mg/kg, n = 6) or vehicle control (n = 11). We controlled mean arterial pressure, hematocrit, and arterial blood gases before and after the intracarotid embolization of an autologous clot. Cerebral blood flow (cm3/100 g/min) (mean +/- SEM) was immediately reduced from 55.2 +/- 7.7 to 8.5 +/- 2.5 in the control group and from 61.8 +/- 14.8 to 10.0 +/- 3.5 in the treated group after embolization. Cerebral blood flow recovered significantly within 60 minutes of thrombolytic therapy and attained a value of 59.6 +/- 10.0 cm3/100 g/min 4 hours after embolization, whereas cerebral blood flow in control animals demonstrated only a minimal recovery to 15.3 +/- 8.9 cm3/100 g/min. Cerebral infarct size (percent of hemisphere) was reduced from 34.4 +/- 5.6% in control animals to 8.8 +/- 5.6% in treated animals (mean +/- SEM, p less than 0.01). These results suggest that tissue plasminogen activator may be efficacious in restoring cerebral blood flow and thus limiting infarct size in acute thromboembolic stroke.

Author List

Bednar MM, McAuliffe T, Raymond S, Gross CE

Author

Timothy L. McAuliffe PhD Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Arteries
Brain
Carbon Dioxide
Cerebrovascular Circulation
Cerebrovascular Disorders
Female
Intracranial Embolism and Thrombosis
Intracranial Pressure
Male
Oxygen
Rabbits
Tissue Plasminogen Activator