Pancreatitis associated with bone marrow transplantation in children. Bone Marrow Transplant 1992 Jul;10(1):65-9
Date
07/01/1992Pubmed ID
1515881Scopus ID
2-s2.0-0026673086 (requires institutional sign-in at Scopus site) 32 CitationsAbstract
Vomiting, abdominal pain and distension, common findings in children who receive bone marrow transplants (BMT), are usually attributed to chemo-irradiation and mucositis, universally found in these patients. We report seven children, 3.5% of BMT patients at our institutions, with these symptoms who were found to have mild to severe pancreatitis during conditioning for or after receiving BMT. All patients were receiving drugs known to cause pancreatitis, such as adrenocorticosteroids and sulfonamides as well as numerous putative pancreatotoxins such as cyclosporin A and cytosine arabinoside. Five of the seven patients had suffered from graft-versus-host disease. In patients who have received BMT, upper gastrointestinal symptoms should not be attributed to mucositis or chemo-irradiation without first testing for pancreatitis.
Author List
Werlin SL, Casper J, Antonson D, Calabro CAuthors
James Casper MD Emeritus Professor in the Pediatrics department at Medical College of WisconsinSteven L. Werlin MD Emeritus Professor in the Pediatrics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdolescentBone Marrow Transplantation
Child
Child, Preschool
Female
Graft vs Host Disease
Humans
Male
Pancreatitis
Time Factors
