Faculty Collaboration Database

Postprandial effects on electrolyte homeostasis in the kidney. Am J Physiol Renal Physiol 2019 Dec 01;317(6):F1405-F1408

Date

10/01/2019

Pubmed ID

31566434

Pubmed Central ID

PMC6960787

DOI

10.1152/ajprenal.00350.2019

Scopus ID

2-s2.0-85075958423 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

Insulin is known to be an important regulator of a number of different channels and transporters in the kidney, but its role in the kidney to prevent Na⁺ and volume loss during the osmotic load after a meal has only recently been validated. With increasing numbers of people suffering from diabetes and hypertension, furthering our understanding of insulin signaling and renal Na⁺ handling in both normal and diseased states is essential for improving patient treatments and outcomes. The present review is focused on postprandial effects on Na⁺ reabsorption in the kidney and the role of the epithelial Na⁺ channels as an important channel contributing to insulin-mediated Na⁺ reclamation.

Author List

Klemens CA, Brands MW, Staruschenko A

MESH terms used to index this publication - Major topics in bold

Animals
Homeostasis
Humans
Kidney
Postprandial Period
Water-Electrolyte Balance