The T(reg)/Th17 cell balance: a new paradigm for autoimmunity. Pediatr Res 2009 May;65(5 Pt 2):26R-31R
Date
02/17/2009Pubmed ID
19218879DOI
10.1203/PDR.0b013e31819e76c7Scopus ID
2-s2.0-68049130978 (requires institutional sign-in at Scopus site) 174 CitationsAbstract
Regulatory T cells and T helper 17 cells are two recently described lymphocyte subsets with opposing actions. In this review, we discuss the mechanisms that promote development of these cells from common precursors and the specific factors that impact their cell numbers and function. Altered regulation of this key developmental checkpoint may contribute to the pathophysiology of autoimmune diseases by tipping the balance toward inflammation. We also present recent findings that suggest how the equilibrium between regulatory T cells and proinflammatory T helper subsets might be pharmacologically restored for therapeutic benefit.
Author List
Eisenstein EM, Williams CBAuthor
Calvin B. Williams MD, PhD Chief, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAutoimmune Diseases
Autoimmunity
Cell Differentiation
Humans
Mice
T-Lymphocytes, Helper-Inducer
T-Lymphocytes, Regulatory
