Medical College of Wisconsin
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Early-life course socioeconomic factors and chronic kidney disease. Adv Chronic Kidney Dis 2015 Jan;22(1):16-23



Pubmed ID




Scopus ID

2-s2.0-84920263374   21 Citations


Kidney failure or ESRD affects approximately 650,000 Americans, whereas the number with earlier stages of CKD is much higher. Although CKD and ESRD are usually associated with adulthood, it is likely that the initial stages of CKD begin early in life. Many of these pathways are associated with low birth weight and disadvantaged socioeconomic status (SES) in childhood, translating childhood risk into later-life CKD and kidney failure. Social factors are thought to be fundamental causes of disease. Although the relationship between adult SES and CKD has been well established, the role of early childhood SES for CKD risk remains obscure. This review provides a rationale for examining the association between early-life SES and CKD. By collecting data on early-life SES and CKD, the interaction with other periods in the life course could also be studied, allowing for examination of whether SES trajectories (eg, poverty followed by affluence) or cumulative burden (eg, poverty at multiple time points) are more relevant to lifetime CKD risk.

Author List

Brophy PD, Shoham DA, CKD Life Course Group, Charlton JR, Carmody J, Reidy KJ, Harshman L, Segar J, Askenazi D


Jeffrey L. Segar MD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Disease Progression
Health Status Disparities
Premature Birth
Prenatal Exposure Delayed Effects
Renal Insufficiency, Chronic
Risk Factors
Social Class
Socioeconomic Factors
United States
jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0