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Interactive effects of age and recent substance use on striatal shape morphology at substance use disorder treatment entry. Drug Alcohol Depend 2020 Jan 01;206:107728

Date

11/20/2019

Pubmed ID

31740207

Pubmed Central ID

PMC6980652

DOI

10.1016/j.drugalcdep.2019.107728

Scopus ID

2-s2.0-85075523246 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

BACKGROUND: Striatal neuroadaptations are regarded to play an important role in the progression from voluntary to compulsive use of addictive substances and provide a promising target for the identification of neuroimaging biomarkers. Recent advances in surface-based computational analysis enable morphological assessment linking variations in global and local striatal shape to duration and magnitude of substance use with a degree of sensitivity that exceeds standard volumetric analysis.

METHODS: This study used a new segmentation methodology coupled with local surface-based indices of surface area and displacement to provide a comprehensive structural characterization of the striatum in 34 patients entering treatment for substance use disorder (SUD) and 49 controls, and to examine the influence of recent substance use on abnormal age-related striatal deformation in SUD patients.

RESULTS: Patients showed a small reduction in striatal volume and no difference in surface area or shape in comparison to controls. Between-group differences in shape were likely neutralized by the bidirectional influence of recent substance use on striatal shape in SUD patients. Specifically, there was an interaction between age and substance such that among older patients more drug use was associated with greater inward striatal contraction but more alcohol use was associated with greater outward expansion.

CONCLUSIONS: This study builds on previous work and advances our understanding of the nature of striatal neuroadaptations as a potential biomarker of disease progression in addiction.

Author List

Copersino ML, Patel R, Price JS, Visser KF, Vitaliano G, Plitman E, Lukas SE, Weiss RD, Janes AC, Chakravarty MM

Author

Jenessa Price PhD Associate Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Age Factors
Biomarkers
Computational Biology
Corpus Striatum
Disease Progression
Female
Humans
Male
Organ Size
Substance-Related Disorders