EBNA1, EBNA2, and EBNA3 link Epstein-Barr virus and hypovitaminosis D in multiple sclerosis pathogenesis. J Neuroimmunol 2020 Feb 15;339:577116
Date
12/06/2019Pubmed ID
31805475DOI
10.1016/j.jneuroim.2019.577116Scopus ID
2-s2.0-85075733265 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
A strong north-to-south gradient is observed in the distribution of multiple sclerosis (MS), hinting toward an environmental etiology. Vitamin D has been associated with a decreased incidence of MS and may explain, in part, the lower prevalence in tropical climates. However, the existence of MS epidemics implies the possibility of an infectious etiology. Epstein-Barr virus (EBV) infection precedes MS presentation in nearly all affected individuals. While the individual contribution of EBV, vitamin D deficiency, and specific risk genes to MS etiology is possible, their potential interaction is of great interest and may have a synergistic effect on the development of MS.
Author List
Marcucci SB, Obeidat AZAuthor
Ahmed Zayed Obeidat MD, PhD Associate Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Epstein-Barr Virus InfectionsEpstein-Barr Virus Nuclear Antigens
Humans
Multiple Sclerosis
Viral Proteins
Vitamin D
Vitamin D Deficiency
