Expression, localization, and functional properties of inwardly rectifying K+ channels in the kidney. Am J Physiol Renal Physiol 2020 Feb 01;318(2):F332-F337
Date
12/17/2019Pubmed ID
31841387Pubmed Central ID
PMC7052651DOI
10.1152/ajprenal.00523.2019Scopus ID
2-s2.0-85078686939 (requires institutional sign-in at Scopus site) 14 CitationsAbstract
Inwardly rectifying K+ (Kir) channels are expressed in multiple organs and cell types and play critical roles in cellular function. Most notably, Kir channels are major determinants of the resting membrane potential and K+ homeostasis. The renal outer medullary K+ channel (Kir1.1) was the first renal Kir channel identified and cloned in the kidney over two decades ago. Since then, several additional members, including classical and ATP-regulated Kir family classes, have been identified to be expressed in the kidney and to contribute to renal ion transport. Although the ATP-regulated Kir channel class remains the most well known due to severe pathological phenotypes associated with their mutations, progress is being made in defining the properties, localization, and physiological functions of other renal Kir channels, including those localized to the basolateral epithelium. This review is primarily focused on the current knowledge of the expression and localization of renal Kir channels but will also briefly describe their proposed functions in the kidney.
Author List
Manis AD, Hodges MR, Staruschenko A, Palygin OAuthor
Matthew R. Hodges PhD Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsGene Expression Regulation
Homeostasis
Humans
Kidney
Kidney Diseases
Membrane Potentials
Potassium
Potassium Channels, Inwardly Rectifying
