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A new model of glucocorticoid-induced metanephric maldevelopment. Experientia 1984 May 15;40(5):489-90

Date

05/15/1984

Pubmed ID

6723915

DOI

10.1007/BF01952400

Scopus ID

2-s2.0-0021282316 (requires institutional sign-in at Scopus site)   20 Citations

Abstract

A new experimental model of glucocorticoid-induced tubular cyst formation has been developed in metanephric organ culture. The addition of cortisol (1.4 X 10(-5) M) to chemically defined serum-free culture medium produces cystic changes during in vitro nephrogenesis . The model isolates the role of glucocorticoids in experimental cyst formation.

Author List

Avner ED, Sweeney WE Jr, Piesco NP, Ellis D

Author

Ellis D. Avner MD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Glucocorticoids
Kidney
Kidney Diseases, Cystic
Mice
Organ Culture Techniques