ANCA-positive IgA nephropathy without necrotising or crescentic glomerulonephritis: a clinical conundrum. BMJ Case Rep 2017 Nov 23;2017
Date
11/25/2017Pubmed ID
29170179Pubmed Central ID
PMC5720328DOI
10.1136/bcr-2017-222171Scopus ID
2-s2.0-85035048887 (requires institutional sign-in at Scopus site) 1 CitationAbstract
IgA nephropathy, the most prevalent form of primary glomerular disease, usually portends a favourable outcome. Antineutrophil cytoplasmic autoantibodies (ANCAs) have been reported in association with IgA nephropathy in a small subset of patients, mostly presenting with rapidly progressive glomerulonephritis and necrotising crescentic lesions. Herein, we describe a case of IgA nephropathy, positive serum cytoplasmic and perinuclear ANCAs with anti-myeloperoxidase antibody, and preserved renal function without any histological evidence of necrotising or crescentic glomerulonephritis. Based on available mechanistic and clinical data, we opine that such patients could benefit from close monitoring of renal function.
Author List
Koratala A, Zeng X, Kazory AAuthor
Abhilash Koratala MD Associate Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAntibodies, Antineutrophil Cytoplasmic
Autoantibodies
Female
Glomerulonephritis, IGA
Humans
Kidney
Peroxidase