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ANCA-positive IgA nephropathy without necrotising or crescentic glomerulonephritis: a clinical conundrum. BMJ Case Rep 2017 Nov 23;2017

Date

11/25/2017

Pubmed ID

29170179

Pubmed Central ID

PMC5720328

DOI

10.1136/bcr-2017-222171

Abstract

IgA nephropathy, the most prevalent form of primary glomerular disease, usually portends a favourable outcome. Antineutrophil cytoplasmic autoantibodies (ANCAs) have been reported in association with IgA nephropathy in a small subset of patients, mostly presenting with rapidly progressive glomerulonephritis and necrotising crescentic lesions. Herein, we describe a case of IgA nephropathy, positive serum cytoplasmic and perinuclear ANCAs with anti-myeloperoxidase antibody, and preserved renal function without any histological evidence of necrotising or crescentic glomerulonephritis. Based on available mechanistic and clinical data, we opine that such patients could benefit from close monitoring of renal function.

Author List

Koratala A, Zeng X, Kazory A

Author

Abhilash Koratala MD Assistant Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Antibodies, Antineutrophil Cytoplasmic
Autoantibodies
Female
Glomerulonephritis, IGA
Humans
Kidney
Peroxidase