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Gammaherpesviruses and B Cells: A Relationship That Lasts a Lifetime. Viral Immunol 2020 05;33(4):316-326

Date

01/09/2020

Pubmed ID

31913773

Pubmed Central ID

PMC7247026

DOI

10.1089/vim.2019.0126

Scopus ID

2-s2.0-85084694556   1 Citation

Abstract

Gammaherpesviruses are highly prevalent pathogens that establish life-long infection and are associated with diverse malignancies, including lymphoproliferative diseases and B cell lymphomas. Unlike other viruses that either do not infect B cells or infect B cells transiently, gammaherpesviruses manipulate physiological B cell differentiation to establish life-long infection in memory B cells. Disruption of such viral manipulation by genetic or environmental causes is likely to seed viral lymphomagenesis. In this review, we discuss physiological and unique host and viral mechanisms usurped by gammaherpesviruses to fine tune host B cell biology for optimal infection establishment and maintenance.

Author List

Johnson KE, Tarakanova VL

Author

Vera Tarakanova PhD Associate Professor in the Microbiology and Immunology department at Medical College of Wisconsin




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