Medical College of Wisconsin
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Methoxyindoles and photoreceptor metabolism: activation of rod shedding. Science 1983 Mar 18;219(4590):1341-3

Date

03/18/1983

Pubmed ID

6828862

DOI

10.1126/science.6828862

Scopus ID

2-s2.0-0020568959 (requires institutional sign-in at Scopus site)   159 Citations

Abstract

Using an in vitro eye-cup preparation, we have evaluated a potential relationship between methoxyindole metabolism and photoreceptor disk shedding. Melatonin, 6-chloromelatonin, and 5-methoxytryptophol all activate rod disk shedding in culture. The effect is compound specific since serotonin and N-acetylserotonin are without effect, and it is similar to shedding in vivo because it is evoked by light and is quantitatively comparable to a normal intact animal response. The results suggest the involvement of 5-methoxyindoles in the control of rhythmic photoreceptor metabolism.

Author List

Besharse JC, Dunis DA

Author

Joseph C. Besharse PhD, MA Emeritus Professor in the Cell Biology Neurobiology and Anatomy department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
In Vitro Techniques
Indoles
Melatonin
Phagocytosis
Photoreceptor Cells
Xenopus laevis