Faculty Collaboration Database

The Endocardium and Heart Valves. Cold Spring Harb Perspect Biol 2020 Dec 01;12(12)

Date

01/29/2020

Pubmed ID

31988139

Pubmed Central ID

PMC7382980

DOI

10.1101/cshperspect.a036723

Scopus ID

2-s2.0-85083345940 (requires institutional sign-in at Scopus site)   22 Citations

Abstract

Endocardial cells are specialized endothelial cells that, during embryogenesis, form a lining on the inside of the developing heart, which is maintained throughout life. Endocardial cells are an essential source for several lineages of the cardiovascular system including coronary endothelium, endocardial cushion mesenchyme, cardiomyocytes, mural cells, fibroblasts, liver vasculature, adipocytes, and hematopoietic cells. Alterations in the differentiation programs that give rise to these lineages has detrimental effects, including premature lethality or significant structural malformations present at birth. Here, we will review the literature pertaining to the contribution of endocardial cells to valvular, and nonvalvular lineages and highlight critical pathways required for these processes. The lineage differentiation potential of embryonic, and possibly adult, endocardial cells has therapeutic potential in the regeneration of damaged cardiac tissue or treatment of cardiovascular diseases.

Author List

Dye B, Lincoln J

Author

Joy Lincoln PhD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Embryonic Development
Endocardial Cushions
Endocardium
Heart Valves
Humans
Myocardium
Signal Transduction