Faculty Collaboration Database

A computer model of the pediatric circulatory system for testing pediatric assist devices. ASAIO J 2007;53(1):74-81

Date

01/24/2007

Pubmed ID

17237652

DOI

10.1097/01.mat.0000247154.02260.30

Scopus ID

2-s2.0-33846458303 (requires institutional sign-in at Scopus site)   13 Citations

Abstract

Lumped parameter computer models of the pediatric circulatory systems for 1- and 4-year-olds were developed to predict hemodynamic responses to mechanical circulatory support devices. Model parameters, including resistance, compliance and volume, were adjusted to match hemodynamic pressure and flow waveforms, pressure-volume loops, percent systole, and heart rate of pediatric patients (n = 6) with normal ventricles. Left ventricular failure was modeled by adjusting the time-varying compliance curve of the left heart to produce aortic pressures and cardiac outputs consistent with those observed clinically. Models of pediatric continuous flow (CF) and pulsatile flow (PF) ventricular assist devices (VAD) and intraaortic balloon pump (IABP) were developed and integrated into the heart failure pediatric circulatory system models. Computer simulations were conducted to predict acute hemodynamic responses to PF and CF VAD operating at 50%, 75% and 100% support and 2.5 and 5 ml IABP operating at 1:1 and 1:2 support modes. The computer model of the pediatric circulation matched the human pediatric hemodynamic waveform morphology to within 90% and cardiac function parameters with 95% accuracy. The computer model predicted PF VAD and IABP restore aortic pressure pulsatility and variation in end-systolic and end-diastolic volume, but diminish with increasing CF VAD support.

Author List

Giridharan GA, Koenig SC, Mitchell M, Gartner M, Pantalos GM

Author

Michael Edward Mitchell MD Chief, Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Blood Pressure
Child, Preschool
Computer Simulation
Coronary Circulation
Heart Rate
Heart-Assist Devices
Humans
Infant
Intra-Aortic Balloon Pumping
Models, Cardiovascular
Pulsatile Flow
Ventricular Function, Left