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Synthesis and Biological Evaluation of Tryptamines Found in Hallucinogenic Mushrooms: Norbaeocystin, Baeocystin, Norpsilocin, and Aeruginascin. J Nat Prod 2020 Feb 28;83(2):461-467

Date

02/23/2020

Pubmed ID

32077284

DOI

10.1021/acs.jnatprod.9b01061

Scopus ID

2-s2.0-85080029383 (requires institutional sign-in at Scopus site)   53 Citations

Abstract

A general synthetic method was developed to access known tryptamine natural products present in psilocybin-producing mushrooms. In vitro and in vivo experiments were then conducted to inform speculations on the psychoactive properties, or lack thereof, of the natural products. In animal models, psychedelic activity by baeocystin alone was not evident using the mouse head twitch response assay, despite its putative dephosphorylated metabolite, norpsilocin, possessing potent agonist activity at the 5-HT2A receptor.

Author List

Sherwood AM, Halberstadt AL, Klein AK, McCorvy JD, Kaylo KW, Kargbo RB, Meisenheimer P

Author

John McCorvy PhD Associate Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Agaricales
Alkaloids
Animals
Hallucinogens
Indoles
Mice
Molecular Structure
Organophosphates
Organophosphorus Compounds
Psilocybin
Tryptamines