Medical College of Wisconsin
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Pharmacologic Treatment Strategies for Nonalcoholic Steatohepatitis. Gastroenterol Clin North Am 2020 Mar;49(1):105-121

Date

02/09/2020

Pubmed ID

32033758

DOI

10.1016/j.gtc.2019.10.003

Scopus ID

2-s2.0-85078856616 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a common form of liver disease, associated with features of the metabolic syndrome. Nonalcoholic steatohepatitis (NASH), the aggressive subtype of NAFLD, can cause progressive fibrosis leading to cirrhosis. With the obesity epidemic, there is an increased health care burden from NASH, one of the most common causes of liver transplantation in the United States. There currently are no Food and Drug Administration-approved medical therapies for NASH. There exists a need for therapeutics to correct the drivers of NASH and to reverse or halt fibrosis progression. This article reviews pharmacologic therapeutics being developed to treat NASH.

Author List

Esteban JPG, Asgharpour A

Author

James Esteban MD Assistant Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Humans
Non-alcoholic Fatty Liver Disease