Distribution of glucose incorporated into macromolecular material by treponema pallidum. Infect Immun 1981 Mar;31(3):1071-7
Date
03/01/1981Pubmed ID
7014454Pubmed Central ID
PMC351426DOI
10.1128/iai.31.3.1071-1077.1981Scopus ID
2-s2.0-0019506205 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
Treponema pallidum was observed to incorporate glucose carbons into lipids, ribonucleic acid, deoxyribonucleic acid, and protein. Only the glycerol portions of phosphatidylcholine and phosphatidylglycerol contained glucose-derived carbons. Incorporation of exogenous choline into phosphatidylcholine was detected. Glucose was incorporated into only the pentoses of nucleic acids. About 50% of the glucose incorporated into protein was present in only one amino acid, aspartate. Evidence suggests that aspartate synthesis could follow the conversion of phosphoenolpyruvate to oxalacetic acid by a guanosine 5'-diphosphate-dependent phosphoenolpyruvate carboxykinase.
Author List
Barbieri JT, Austin FE, Cox CDAuthor
Joseph T. Barbieri PhD Professor in the Microbiology and Immunology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsGlucose
Leucine
Lipids
Nucleic Acids
Oxaloacetates
Phosphoenolpyruvate Carboxykinase (GTP)
Protein Biosynthesis
Treponema pallidum
